Neurotrophins Prevent Death and Differentially Affect Tyrosine Hydroxylase of Adult Rat Nigrostriatal Neurons in Vivo
Identifieur interne : 003959 ( Main/Exploration ); précédent : 003958; suivant : 003960Neurotrophins Prevent Death and Differentially Affect Tyrosine Hydroxylase of Adult Rat Nigrostriatal Neurons in Vivo
Auteurs : Theo Hagg [Canada]Source :
- Experimental Neurology [ 0014-4886 ] ; 1998.
English descriptors
- KwdEn :
Abstract
Brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) promote survival of mesencephalic dopaminergic neuronsin vitroand affect normal and damaged onesin vivo.Here, these neurotrophins had markedly different potencies to prevent the death of axotomized nigrostriatal dopaminergic neurons when infused close to the rostral end of the nigral nucleus of adult rats (NT-4>BDNF>NT-3; nerve growth factor or NGF without effect). With a high dose of BDNF (30 μg/day) complete protection was achieved in the rostral but not caudal nigral regions, consistent with its poor diffusion characteristics in brain tissue. Measurements of tyrosine hydroxylase immunoreactivity suggest that BDNF and NT-4 (presumably through their TrkB receptor) reduce the synthesis of this rate-limiting enzyme for dopamine synthesis in rescued as well as in normal neurons. In sharp contrast, survival-promoting doses of NT-3 (presumably through its TrkC receptor) maintained normal levels of tyrosine hydroxylase immunoreactivity in the rescued nigrostriatal neurons. These results suggest that for these adult central nervous system neurons, some neurotrophic factors are predominantly involved in facilitating cell survival, whereas others are more involved in regulating neurotransmitter function.
Url:
DOI: 10.1006/exnr.1997.6684
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001289
- to stream Istex, to step Curation: 001289
- to stream Istex, to step Checkpoint: 001517
- to stream Main, to step Merge: 003F74
- to stream Main, to step Curation: 003959
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neurotrophins Prevent Death and Differentially Affect Tyrosine Hydroxylase of Adult Rat Nigrostriatal Neurons in Vivo</title><author><name sortKey="Hagg, Theo" sort="Hagg, Theo" uniqKey="Hagg T" first="Theo" last="Hagg">Theo Hagg</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:5B94F25B9F7A81B49BF55320626F527A1E24A1A1</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1006/exnr.1997.6684</idno><idno type="url">https://api-v5.istex.fr/document/5B94F25B9F7A81B49BF55320626F527A1E24A1A1/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001289</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001289</idno><idno type="wicri:Area/Istex/Curation">001289</idno><idno type="wicri:Area/Istex/Checkpoint">001517</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001517</idno><idno type="wicri:doubleKey">0014-4886:1998:Hagg T:neurotrophins:prevent:death</idno><idno type="wicri:Area/Main/Merge">003F74</idno><idno type="wicri:Area/Main/Curation">003959</idno><idno type="wicri:Area/Main/Exploration">003959</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Neurotrophins Prevent Death and Differentially Affect Tyrosine Hydroxylase of Adult Rat Nigrostriatal Neurons in Vivo</title><author><name sortKey="Hagg, Theo" sort="Hagg, Theo" uniqKey="Hagg T" first="Theo" last="Hagg">Theo Hagg</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, B3H 4H7</wicri:regionArea><wicri:noRegion>B3H 4H7</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Experimental Neurology</title><title level="j" type="abbrev">YEXNR</title><idno type="ISSN">0014-4886</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">149</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="183">183</biblScope><biblScope unit="page" to="192">192</biblScope></imprint><idno type="ISSN">0014-4886</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-4886</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson</term><term>axotomy</term><term>brain-derived neurotrophic factor</term><term>neuronal death</term><term>neurotrophic factor</term><term>neurotrophin-3</term><term>neurotrophin-4</term><term>neurotrophin-4/5</term><term>nigrostriatal</term><term>substantia nigra.</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4) promote survival of mesencephalic dopaminergic neuronsin vitroand affect normal and damaged onesin vivo.Here, these neurotrophins had markedly different potencies to prevent the death of axotomized nigrostriatal dopaminergic neurons when infused close to the rostral end of the nigral nucleus of adult rats (NT-4>BDNF>NT-3; nerve growth factor or NGF without effect). With a high dose of BDNF (30 μg/day) complete protection was achieved in the rostral but not caudal nigral regions, consistent with its poor diffusion characteristics in brain tissue. Measurements of tyrosine hydroxylase immunoreactivity suggest that BDNF and NT-4 (presumably through their TrkB receptor) reduce the synthesis of this rate-limiting enzyme for dopamine synthesis in rescued as well as in normal neurons. In sharp contrast, survival-promoting doses of NT-3 (presumably through its TrkC receptor) maintained normal levels of tyrosine hydroxylase immunoreactivity in the rescued nigrostriatal neurons. These results suggest that for these adult central nervous system neurons, some neurotrophic factors are predominantly involved in facilitating cell survival, whereas others are more involved in regulating neurotransmitter function.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Hagg, Theo" sort="Hagg, Theo" uniqKey="Hagg T" first="Theo" last="Hagg">Theo Hagg</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003959 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003959 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:5B94F25B9F7A81B49BF55320626F527A1E24A1A1
|texte= Neurotrophins Prevent Death and Differentially Affect Tyrosine Hydroxylase of Adult Rat Nigrostriatal Neurons in Vivo
}}
| This area was generated with Dilib version V0.6.29. |  |